abstract：:We developed an open-access, Excel-based model simulating currently recommended and alternative algorithms for adult HIV testing as a preliminary investigation of trade-offs between accuracy and costs. Despite higher costs, simpler HIV testing algorithms incorporating point of care nucleic acid testing may improve out...

journal_title：Open forum infectious diseases

authors： Neilan AM,Cohn JE,Lemaire JF,Sacks E,Alban R,Freedberg KA,Walensky RP,Ciaranello AL

更新日期：2018-08-29 00:00:00

abstract：:Mycobacterium abscessus is a rapidly growing, multidrug-resistant mycobacteria, commonly associated with pulmonary, skin, and soft tissue infections. We describe a rare case of M abscessus endovascular stent infection; only 3 cases of graft infections have previously been reported. ...

journal_title：Open forum infectious diseases

authors： Tejura N,Bontempo G,Chew D

更新日期：2018-08-23 00:00:00

abstract：Background:We estimated and characterized the proportion of patients living with HIV (PLWH) who missed hepatitis C (HCV) intake appointments and subsequently failed to establish HCV care. Methods:Logistic regression analyses were used to identify factors associated with missed HCV intake appointments and failure to es...

journal_title：Open forum infectious diseases

authors： Cachay ER,Hill L,Torriani F,Ballard C,Grelotti D,Aquino A,Christopher Mathews W

更新日期：2018-07-31 00:00:00

abstract：Background:Non-US-born individuals account for the majority of active tuberculosis (TB) in the United States. Interferon gamma release assay (IGRA) is the preferred diagnostic test for latent TB but can produce an indeterminate result. We investigated the prevalence and predictors of an indeterminate IGRA (IND-IGRA) in...

journal_title：Open forum infectious diseases

authors： Sharninghausen JC,Shapiro AE,Koelle DM,Kim HN

更新日期：2018-07-27 00:00:00

abstract：:In this brief report, we describe a 76-year-old patient with thymoma who underwent craniotomy for a left parietal lobe mass with pathologic findings consistent with Toxoplasma gondii encephalitis in the absence of any features of thymoma with immunodeficiency/Good's syndrome. His clinical course suggested likely Toxop...

journal_title：Open forum infectious diseases

authors： Chastain DB,Sams JI,Steele GM,Lowder LO,Franco-Paredes C

更新日期：2018-07-07 00:00:00

abstract：Background:Internal medicine physicians are often the first providers to encounter patients with a new diagnosis of tuberculosis. Given the public health risks of missed tuberculosis cases, assessing internal medicine residents' ability to diagnose tuberculosis is important. Methods:Internal medicine resident knowledg...

journal_title：Open forum infectious diseases

authors： Chida N,Brown C,Mathad J,Carpenter K,Nelson G,Schechter MC,Giles N,Rebolledo PA,Ray S,Fabre V,Cantillo DS,Longworth S,Amorosa V,Petrauskis C,Boulanger C,Cain N,Gupta A,McKenzie-White J,Bollinger R,Melia MT

更新日期：2018-06-27 00:00:00

abstract：:Health-related quality of life (HRQoL) in outpatient parenteral antimicrobial therapy (OPAT) has not been well characterized in the United States. In an OPAT cohort, the short-form-12's median physical component score and mental component score were 40.3 and 54.4, respectively. HRQoL measures could be helpful in studi...

journal_title：Open forum infectious diseases

authors： Keller SC,Williams D,Levering M,Cosgrove SE

更新日期：2018-06-20 00:00:00

abstract：Background:Vaccines have been used successfully for disease elimination programs in many countries. Evidence on the impact of vaccination programs can support decision-making among medical practitioners and policy makers to improve immunization rates. We estimated the health and economic impact of measles vaccination f...

journal_title：Open forum infectious diseases

authors： Paternina-Caicedo A,Driessen J,Roberts M,van Panhuis WG

更新日期：2018-06-16 00:00:00

abstract：Background:Recent studies have favored the use of cefazolin over nafcillin for the treatment of methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia. The clinical influence of the cefazolin inoculum effect (CzIE) in the effectiveness of cephalosporins for severe MSSA infections has not been evaluated. Metho...

journal_title：Open forum infectious diseases

authors： Miller WR,Seas C,Carvajal LP,Diaz L,Echeverri AM,Ferro C,Rios R,Porras P,Luna C,Gotuzzo E,Munita JM,Nannini E,Carcamo C,Reyes J,Arias CA

更新日期：2018-05-23 00:00:00

abstract：:Passive surveillance data had signaled the possibility of gastrointestinal adverse events occurring after the administration of high-dose inactivated influenza vaccine (IIV-HD). However, in a large, prospective randomized clinical trial, rates of serious gastrointestinal events were no greater among IIV-HD recipients ...

journal_title：Open forum infectious diseases

authors： Talbot HK,Dunning AJ,Robertson CA,Landolfi VA,Greenberg DP,DiazGranados CA

更新日期：2018-05-22 00:00:00

abstract：Background:Antibiotic-resistant bacterial infections are a major threat to public health, yet improper use of antibiotics remains high. Infectious Diseases (ID) fellows play a major role in antibiotic stewardship efforts, but there is little research on how they view stewardship activities. We performed a qualitative s...

journal_title：Open forum infectious diseases

authors： Morgan JR,Barlam TF,Drainoni ML

更新日期：2018-05-03 00:00:00

abstract：Background:The 13-valent pneumococcal conjugate vaccine (PCV13) and the 23-valent pneumococcal polysaccharide vaccine (PPSV23) were both recommended to adults aged ≥65 years. The study examines adults ≥65 years for risk of adverse events (AEs) requiring medical attention following vaccination with PCV13 as compared wit...

journal_title：Open forum infectious diseases

authors： Tseng HF,Sy LS,Qian L,Liu IA,Mercado C,Lewin B,Tartof SY,Nelson J,Jackson LA,Daley MF,Weintraub E,Klein NP,Belongia E,Liles EG,Jacobsen SJ

更新日期：2018-05-02 00:00:00

abstract：Background:In 2012, the US Food and Drug Administration (FDA) required drug manufacturers to give advance notice of impending drug shortages. A survey of infectious diseases (ID) physicians was undertaken to determine the impact of this requirement and to follow-up on prior perceptions of ID physicians on shortages of ...

journal_title：Open forum infectious diseases

authors： Gundlapalli AV,Beekmann SE,Graham DR,Polgreen PM,Members of the Emerging Infections Network.

更新日期：2018-04-23 00:00:00

abstract：Background:The number of invasive group A Streptococcus (iGAS) infections due to hitherto extremely rare type emm74 strains has increased in several Canadian provinces since late 2015. We hypothesized that the cases recorded in the different provinces are linked and caused by strains of an emm74 clone that recently eme...

journal_title：Open forum infectious diseases

authors： Teatero S,McGeer A,Tyrrell GJ,Hoang L,Smadi H,Domingo MC,Levett PN,Finkelstein M,Dewar K,Plevneshi A,Athey TBT,Gubbay JB,Mulvey MR,Martin I,Demczuk W,Fittipaldi N

更新日期：2018-04-20 00:00:00

abstract：:We report a family who acquired acute toxoplasmosis after a trip to Central America. One member developed severe clinical manifestations including bilateral chorioretinitis, hepatitis, and myocarditis requiring therapy. Symptomatic acute toxoplasmosis is unusual and possesses a diagnostic challenge. We discuss the cli...

journal_title：Open forum infectious diseases

authors： Henao-Martínez AF,Franco-Paredes C,Palestine AG,Montoya JG

更新日期：2018-03-09 00:00:00

abstract：Background:Penicillin allergy frequently impacts antibiotic choice. As beta-lactams are superior to vancomycin in treating methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia, we examined the effect of reported penicillin allergy on clinical outcomes in patients with MSSA bacteremia. Methods:In this retros...

journal_title：Open forum infectious diseases

authors： Turner NA,Moehring R,Sarubbi C,Wrenn RH,Drew RH,Cunningham CK,Fowler VG,Anderson DJ

更新日期：2018-02-19 00:00:00

abstract：:Splenic infarction is a rare complication of infectious mononucleosis. We describe 3 cases of splenic infarction attributed to infectious mononucleosis that we encountered within a 2-month period. We underscore the awareness of this potential complication of infectious mononucleosis and discuss the differential diagno...

journal_title：Open forum infectious diseases

authors： Li Y,George A,Arnaout S,Wang JP,Abraham GM

更新日期：2018-02-17 00:00:00

abstract：Background:Hepatitis C virus (HCV) direct-acting antiviral therapy is effective among people receiving opioid substitution therapy (OST), but studies are limited by small numbers of nongenotype 1 (GT1) patients. The aim of this study was to evaluate the treatment completion, adherence, SVR12, and safety of sofosbuvir-b...

journal_title：Open forum infectious diseases

authors： Grebely J,Feld JJ,Wyles D,Sulkowski M,Ni L,Llewellyn J,Mir HM,Sajed N,Stamm LM,Hyland RH,McNally J,Brainard DM,Jacobson I,Zeuzem S,Bourlière M,Foster G,Afdhal N,Dore GJ

更新日期：2018-02-09 00:00:00

abstract：:[This corrects the article DOI: 10.1093/ofid/ofx156.][This corrects the article DOI: 10.1093/ofid/ofx156.]. ...

journal_title：Open forum infectious diseases

authors：

更新日期：2018-01-30 00:00:00

abstract：Background:Washington, DC, has one of the highest rates of HIV infection in the United States. Sexual intercourse is the leading mode of HIV transmission, and sexually transmitted infections (STIs) are a risk factor for HIV acquisition and transmission. Methods:We evaluated the incidence and demographic factors associ...

journal_title：Open forum infectious diseases

authors： Lucar J,Hart R,Rayeed N,Terzian A,Weintrob A,Siegel M,Parenti DM,Squires LE,Williams R,Castel AD,Benator DA,DC Cohort Executive Committee .

更新日期：2018-01-24 00:00:00

abstract：:We present a case of an unvaccinated traveler who traveled from New York to Peru and contracted yellow fever. He likely acquired the infection while visiting the Amazon River, with a point of exit of Lima, Peru. Our case illustrates the dramatic course that yellow fever may take, as well as the importance of pretravel...

journal_title：Open forum infectious diseases

authors： Winnicka L,Abdullah A,Yang T,Norville K,Irizarry-Acosta M

更新日期：2017-12-20 00:00:00

abstract：Background:Direct acting antiviral hepatitis C virus (HCV) therapies are highly effective but costly. Wider adoption of an 8-week ledipasvir/sofosbuvir treatment regimen could result in significant savings, but may be less efficacious compared with a 12-week regimen. We evaluated outcomes under a constrained budget and...

journal_title：Open forum infectious diseases

authors： Morgan JR,Kim AY,Naggie S,Linas BP

更新日期：2017-12-08 00:00:00

abstract：Background:Recent mumps outbreaks among 2-dose measles mumps rubella (MMR) vaccine recipients have raised questions regarding the potential benefits of a third dose of vaccine (MMR3). If MMR3 provides a sustained elevation in mumps antibody, it may be beneficial for certain at-risk groups or as an outbreak control meas...

journal_title：Open forum infectious diseases

authors： Latner DR,Parker Fiebelkorn A,McGrew M,Williams NJ,Coleman LA,McLean HQ,Rubin S,Hickman CJ

更新日期：2017-12-08 00:00:00

abstract：Background:Mismanagement of asymptomatic patients with positive urine cultures (referred to as asymptomatic bacteriuria [ASB] in the literature) promotes antimicrobial resistance and results in unnecessary antimicrobial-related adverse events and increased health care costs. Methods:We conducted a systematic review an...

journal_title：Open forum infectious diseases

authors： Flokas ME,Andreatos N,Alevizakos M,Kalbasi A,Onur P,Mylonakis E

更新日期：2017-11-20 00:00:00

abstract：Background:Clinical features of Lyme disease (LD) range from localized skin lesions to serious disseminated disease. Information on risk factors for Lyme arthritis, facial palsy, carditis, and meningitis is limited but could facilitate disease recognition and elucidate pathophysiology. Methods:Patients from high-incid...

journal_title：Open forum infectious diseases

authors： Kwit NA,Nelson CA,Max R,Mead PS

更新日期：2017-11-18 00:00:00

abstract：Background:Kindergarten-entry vaccination requirements have played an important role in controlling vaccine-preventable diseases in the United States. Forty-eight states and the District of Colombia offer nonmedical exemptions to vaccines, ranging in stringency. Methods:We analyzed state-level exemption data from 2011...

journal_title：Open forum infectious diseases

authors： Omer SB,Porter RM,Allen K,Salmon DA,Bednarczyk RA

更新日期：2017-11-15 00:00:00

abstract：:Skin and soft tissue infections (SSTI) affect millions of people globally, which represents a significant burden on ambulatory care and hospital settings. The role of sulfamethoxazole-trimethoprim (SXT) in SSTI treatment, particularly when group A Streptococcus (GAS) is involved, is controversial. We conducted a syste...

journal_title：Open forum infectious diseases

authors： Bowen AC,Carapetis JR,Currie BJ,Fowler V Jr,Chambers HF,Tong SYC

更新日期：2017-11-02 00:00:00

abstract：:We report on a case of loiasis revealed during an assisted reproductive technology (ART) cycle. Loa loa could limit implantation outcome. We propose to focus on an ART strategy with frozen embryos to treat the patient before any transfer. ...

journal_title：Open forum infectious diseases

authors： Puy V,Scheffler F,Tinez C,Belhadri-Mansouri N,Huguenin A,Capelle S,Agnamey P,Devaux A,Frydman N,Copin H,Benkhalifa M

更新日期：2017-10-06 00:00:00

abstract：:Cryptococcus gattii infections, especially including those with severe clinical manifestations, may be related to underlying host immunologic factors. We present 2 cases with autoantibodies to granulocyte-macrophage colony-stimulating factor (GM-CSF), a key cytokine in macrophage function. Immunologic evaluation for a...

journal_title：Open forum infectious diseases

authors： Crum-Cianflone NF,Lam PV,Ross-Walker S,Rosen LB,Holland SM

更新日期：2017-10-05 00:00:00

abstract：Background:Delayed pathogen identification and nonspecific clinical findings make definitive decisions regarding antibiotics challenging. The stimuli of bacterial toxins and inflammation make procalcitonin (PCT) unique in its ability to differentiate bacterial infection from other causes of inflammation, and thus it is...

journal_title：Open forum infectious diseases

authors： Broyles MR

更新日期：2017-10-03 00:00:00

abstract：BACKGROUND:Despite the recognized benefit of antiretroviral therapy (ART) for preventing and treating HIV, some studies have reported adverse birth outcomes with in utero ART exposure. We evaluated the effect of infant in utero HIV and ART exposure on preterm delivery (PTD), low birth weight (LBW), small for gestationa...

journal_title：Open forum infectious diseases

authors： Ramokolo V,Goga AE,Lombard C,Doherty T,Jackson DJ,Engebretsen IM

更新日期：2017-08-30 00:00:00

abstract：BACKGROUND:Early diagnosis of human immunodeficiency virus (HIV) is a prerequisite to maximizing individual and societal benefits of antiretroviral therapy. METHODS:Adults ≥18 years of age testing HIV positive at 10 health facilities in Mozambique and Swaziland received point-of-care CD4+ cell count testing immediatel...

journal_title：Open forum infectious diseases

authors： Kujawski SA,Lamb MR,Lahuerta M,McNairy ML,Ahoua L,Abacassamo F,Nuwagaba-Biribonwoha H,Gachuhi A,El-Sadr WM,Elul B

更新日期：2017-07-23 00:00:00

abstract：BACKGROUND:Ombitasvir, paritaprevir with ritonavir, and dasabuvir (OBV/PTV/r ± DSV) ±ribavirin (RBV) are approved to treat hepatitis C virus (HCV) genotype 1 and 4 infection. Here, we investigate the safety and efficacy of OBV/PTV/r + DSV ±RBV for HCV genotype 1, and OBV/PTV/r + RBV for HCV genotype 4, in human immunod...

journal_title：Open forum infectious diseases

authors： Rockstroh JK,Orkin C,Viani RM,Wyles D,Luetkemeyer AF,Lazzarin A,Soto-Malave R,Nelson MR,Bhagani SR,Klinker HHF,Rizzardini G,Girard PM,Tural C,Shulman NS,Mobashery N,Hu YB,Fredrick LM,Pilot-Matias T,Trinh R,Gane E

更新日期：2017-07-22 00:00:00

abstract：:Infection secondary to rapidly growing mycobacteria (RGM) is associated with significant morbidity and mortality, especially in individuals with underlying structural lung disease or immune compromise. Such infections, particularly those caused by the Mycobacterium abscessus group, are challenging to treat due to high...

journal_title：Open forum infectious diseases

authors： McGuffin SA,Pottinger PS,Harnisch JP

更新日期：2017-07-20 00:00:00

abstract：:Jails represent a critical component of the public health response to HCV elimination. We report on outcomes of 104 patients receiving HCV treatment from January 1, 2014 to June 30, 2016 in a large urban jail setting. Our data demonstrate that treatment in jails is feasible, but many barriers remain. ...

journal_title：Open forum infectious diseases

authors： MacDonald R,Akiyama MJ,Kopolow A,Rosner Z,McGahee W,Joseph R,Jaffer M,Venters H

更新日期：2017-07-07 00:00:00

abstract：:During the current Zika virus (ZIKV) outbreak, acute symptomatic ZIKV infection in adults appears to be a mild-to-moderate, self-limited illness. We present a case of ZIKV rash illness that improved and then relapsed without repeat exposure to ZIKV. Clinicians should be alert for relapses in patients with ZIKV infecti...

journal_title：Open forum infectious diseases

authors： Edupuganti S,Natrajan MS,Rouphael N,Lai L,Xu Y,Feldhammer M,Hill C,Patel SM,Johnson SJ,Bower M,Gorchakov R,Berry R,Murray KO,Mulligan MJ

更新日期：2017-06-22 00:00:00

abstract：:The complexity and cost of current diagnostics for hepatitis C virus (HCV) may act as a prevention to the scale-up of treatment in the developing world. Currently, ribonucleic acid (RNA)-polymerase chain reaction tests are the gold standard. However, there is potential for the use of simpler and cheaper antigen tests ...

journal_title：Open forum infectious diseases

authors： Khan H,Hill A,Main J,Brown A,Cooke G

更新日期：2017-05-26 00:00:00

abstract：:Despite the widespread outbreak, few cases of Zika virus associated with cardiac manifestations have been described. We present a case of pericarditis in the setting of an acute, symptomatic Zika virus infection in a traveler returning from St. Thomas. Clinicians should be alert for this potential complication of Zika...

journal_title：Open forum infectious diseases

authors： Waggoner JJ,Rouphael N,Xu Y,Natrajan M,Lai L,Patel SM,Levit RD,Edupuganti S,Mulligan MJ

更新日期：2017-05-18 00:00:00

abstract：:Microvascular function and oxygen consumption affect oxygen homeostasis but have not been assessed in African children with malaria. Microvascular function in Tanzanian children with severe malaria (SM) or uncomplicated malaria were 39% and 72%, respectively, of controls (P < .001). Uncomplicated malaria (P = .04), no...

journal_title：Open forum infectious diseases

authors： Yeo TW,Florence SM,Kalingonji AR,Chen Y,Granger DL,Anstey NM,Mwaikambo ED,Weinberg JB

更新日期：2017-04-22 00:00:00

abstract：BACKGROUND:Human immunodeficiency virus controllers (HICs) form a heterogeneous group of patients with regard to formal definitions, immunologic characteristics, and changes over time in viral load. PATIENTS AND METHODS:The HICs with undetectable viral load ([uHICs] ie, for whom a viral load had never been detected wi...

journal_title：Open forum infectious diseases

authors： Canouï E,Lécuroux C,Avettand-Fenoël V,Gousset M,Rouzioux C,Saez-Cirion A,Meyer L,Boufassa F,Lambotte O,Noël N,and the ANRS CO21 CODEX Study Group.

更新日期：2017-04-03 00:00:00